NICE 2021 guidelines on Cough (acute): Antimicrobial prescribing

According to the committee discussion, acute cough, either associated with an upper respiratory tract infection or acute bronchitis, is usually a self-limiting infection. It is often a viral infection, and antibiotics are not usually needed.

Recommendations on when antibiotics are not required, are required immediately, or as back-up

Recommendations on the choice of antibiotic

  • A narrow-spectrum antibiotic should generally be first choice, when an antibiotic is needed.
  • Where an antibiotic is appropriate, doxycycline at usual dose is recommended, as the first-choice antibiotic for adults with acute cough (including acute bronchitis), in non-pregnant adults, and in young people >12 years.
  • Amoxicillin, clarithromycin or erythromycin should be offered as alternative first choices; for children and young people, amoxicillin is recommended as the first-choice antibiotic in such scenario.

Recommendations on antibiotic course length

  • The shortest course that is likely to be effective should be prescribed. A 5-day course for all the recommended antibiotics is sufficient to treat acute cough.
Reference: Yang CL, Hicks EA, Mitchell PA, et al. Canadian Thoracic Society 2021 Guideline update: Diagnosis and management of asthma in preschoolers, children and adults. Canadian J Resp Crit Care Sleep Med. 2021;5(6): 348–361.